反应详情

To 6.20 ml of an ice-cooled 20% solution of phosgene in toluene was slowly added a solution of 3 g 4-hydroxy-undecanoic acid hex-3-enyl ester and 0.93 g pyridine in 3 ml toluene. The reaction mixture was stirred for 16 hours at room temperature. A mixture of 3.48 g didecylamine and 0.93 g pyridine was added and the mixture was stirred for another 16 hours. Water was added and the mixture extracted with ethyl acetate. The organic layer was washed with saturated sodium bicarbonate, 2N hydrochloric acid, water, dried over magnesium sulfate and evaporated to dryness. The residue was chromatographed on silica gel to give 2.9 g of a colorless liquid.

1. additionwas added
2. stirringthe mixture was stirred for another 16 hours
3. extractionthe mixture extracted with ethyl acetate
4. washThe organic layer was washed with saturated sodium bicarbonate, 2N hydrochloric acid, water
5. dry with materialdried over magnesium sulfate
6. customevaporated to dryness
7. customThe residue was chromatographed on silica gel