Benzaldehyde → DL-beta-Phenylalanine

Participants

Reaction Steps

To 270 mL of ethanol were added 115 g (1.08 mol) of benzaldehyde, 113 g (1.08 mol) of malonic acid, and 167 g (2.16 mol) of ammonium acetate, followed by stirring for 5 hours under heating and refluxing. Precipitated white crystals were filtered and the filtrate was recrystallized from a water-ethanol mixed solvent (1:4, 2.5 L), to give 85.14 g of the title compound (II) as white crystals (yield 48%).

Provenance & Evidence