HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → HCID 23378122, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-(4-iodophenyl)propanoic acid | HCID 2755956 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 23378122 | HCID 23378122 | — |
Reaction Steps
N-Boc-4-iodophenylalanine was dissolved in acetonitrile and DBU (1 equivalent) was added followed by benzyl bromide (1 equivalent). The mixture was stirred for 2 h at room temperature. After removal of the solvent under reduced pressure, the residue was dissolved in EtOAc and the solution washed with 10% aqueous HCl and water. Drying (MgSO4) and concentration under reduced pressure gave a crude product that was purified by crystallization from hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06479508B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-1ab724f7069045f3aad8708925c5505d |
| Source note | uspto-grants-2002_11 |