참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | N-methyl-L-tryptophan | HCID 160511 | — |
| 생성물 | HCID 69317065 | HCID 69317065 | — |
반응 단계
The N-methyltryptophan derivative from above (0.711 g, 1.21 mmol) was dissolved in MeOH (10 mL) and thionyl chloride (0.6 mL) was added dropwise. The mixture was heated to 60° C. for 3 h. Volatiles were removed under reduced pressure and the residue triturated with TBME (25 mL). The precipitated white solid was collected, washed with TBME and dried to give N-methyl-5-hydroxytryptophan methyl ester hydrochloride (0.339 g): MS (ES+) m/z 249 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06479508B1 |
|---|
| 출처 데이터셋 | uspto-grants-2002_11 |
|---|
| ORD ID | ord-87b507d02fbb46c0bbb406f27783d0c1 |
|---|
| 출처 메모 | uspto-grants-2002_11 |
|---|
