HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 491152, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 491151 | HCID 491151 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 491152 | HCID 491152 | — |
Reaction Steps
The title compound of example 115 (6 mg) was dissolved in DMSO (0.4 mL) and 2.5N NaOH (0.2 mL) was added. After stirring for 30 min at room temperature, the reaction mixture was acidified with TFA (0.1 mL) and the product of example 116 isolated directly by preparative C18 reversed-phase HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06479508B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-b2beac7b22164fe790197d14a1fb8e2a |
| Source note | uspto-grants-2002_11 |