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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1018274Generated: October 31, 2026

1-Cyclohexyl-2-(furan-3-yl)-1H-benzimidazole-5-carboxylic acid → Phenylalanine, 4-carboxy-N-[[1-cyclohexyl-2-(3-furanyl)-1H-benzimidazol-5-yl]carbonyl]-3-fluoro-

https://huagongshe.com/reaction/1018274

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Cyclohexyl-2-(furan-3-yl)-1H-benzimidazole-5-carboxylic acidHCID 491113—
ReactantRacemic 3-fluoro-4-(carbomethoxy)phenylalanine methyl ester hydrochlorideHCID 69320128—
ProductPhenylalanine, 4-carboxy-N-[[1-cyclohexyl-2-(3-furanyl)-1H-benzimidazol-5-yl]carbonyl]-3-fluoro-HCID 490785—

Reaction Steps

Racemic 3-fluoro-4-(carbomethoxy)phenylalanine methyl ester hydrochloride (example 119) was coupled to the carboxylic acid of example 2 in the usual manner and saponified to give the title compound of example 120.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06479508B1
Source datasetuspto-grants-2002_11
ORD IDord-b6151bc903e94ab589bdd9272d46afd9
Source noteuspto-grants-2002_11