HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 6476732, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl Acrylate | HCID 7294 | — |
| Reactant | L-Tyrosine, N-(1,1-dimethylethoxy)carbonyl- | HCID 117439 | — |
| Reactant | 1-Cyclohexyl-2-(furan-3-yl)-1H-benzimidazole-5-carboxylic acid | HCID 491113 | — |
| Reactant | 29592-76-5 | HCID 3032857 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 6476732 | HCID 6476732 | — |
Reaction Steps
The iodo tyrosine derivative prepared above was coupled to methyl acrylate according to the procedure of example 83: MS (ES+) m/z 307 (MH+-Boc). The N-Boc-tyrosine derivative prepared above was deprotected with 4 N HCl in dioxane and coupled with the acid of example 2 in the usual manner. Following saponification of the O-acetyl group the title compound of example 142 was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06479508B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-ffa47744cdfa4f0589f4b9ea34ae8bc4 |
| Source note | uspto-grants-2002_11 |