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4-Chloro-2-methylbenzoic acid → HCID 491059、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-2-methylbenzoic acid | HCID 348269 | — |
| 反応物 | HCID 23378470 | HCID 23378470 | — |
| 反応物 | methyl (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoate hydrochloride | HCID 24802218 | — |
| 生成物 | HCID 491059 | HCID 491059 | — |
| 生成物 | HCID 3012619 | HCID 3012619 | — |
反応手順
1-Cyclohexyl-2-furan-3-yl-6-methyl-1H-benzimidazole-5-carboxylic acid was prepared from 4-cyclohexylamino-2-methyl-5-nitrobenzoic acid methyl ester (Example 151) as described for the 4-methyl derivative (Example 151). The acid was coupled to 5-hydroxy-(S)-tryptophan methyl ester hydrochloride in the usual manner and following saponification of the methyl ester and purification by preparative C18 reversed-phase HPLC, the title compound of example 154 was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06479508B1 |
| 出典データセット | uspto-grants-2002_11 |
| ORD ID | ord-76560f347bbc456383d8145d6f78aff0 |
| 出典メモ | uspto-grants-2002_11 |