5-Cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carboxylic Acid → 5-Cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carboxylic Acid (3,5-bis-methoxycarbonyloxymethyl-phenyl)-amide

関与物質

反応手順

5-Cycloheptylmethyl-2-naphthalen-2-yl-1H-imidazole-4-carboxylic acid (Example 20, step c) (605 mg, 1.75 mmol) was reacted with 3,5-bis-methoxycarbonyloxymethyl-aniline (492 mg, 1.75 mmol) according to the procedure of Example 20, step d to afford the product as a white solid (438 mg, 42%). 1H NMR (300 MHz, CDCl3) 9.42 (1H, br s), 9.35 (1H, s), 8.27 (1H, s), 8.06-7.89 (4H, m), 7.79 (2H, s), 7.56 (2H, m), 7.14 (1H, s), 5.18 (4H, s), 3.83 (6H, s), 3.12 (2H, d), 2.00-1.29 (13H, m).

情報源と証拠