Methyl 4-aminobenzoate → HCID 18405631, compound

HRID 1018317Notes

Reaction equation

HRID 1018317 reaction equation
[C:1]12([CH2:11][CH2:12][C:13]3[NH:17][C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[F:24])=[N:15][C:14]=3[C:25](O)=[O:26])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.C[O:29][C:30](=[O:38])[C:31]1[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][CH:32]=1>>[C:1]12([CH2:11][CH2:12][C:13]3[NH:17][C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=4[F:24])=[N:15][C:14]=3[C:25]([NH:37][C:34]3[CH:35]=[CH:36][C:31]([C:30]([OH:29])=[O:38])=[CH:32][CH:33]=3)=[O:26])[CH2:2][CH:3]3[CH2:4][CH:5]([CH2:6][CH:7]([CH2:9]3)[CH2:8]1)[CH2:10]2

Participants

3

Reactant 2

HCID 12082Methyl 4-aminobenzoateHCID 18405648HCID 18405648, compound

Product 1

HCID 18405631HCID 18405631, compound

Procedure

5-(2-Adamantan-1-yl-ethyl)-2-(2-fluoro-phenyl)-1H-imidazole-4-carboxylic acid (Example 50) was reacted with 4-amino-benzoic acid methyl ester according to the procedure of Example 20, step d. Deprotection was carried out using essentially the same procedure as in Example 36, step d to afford the title compound as a white solid.

Sources & evidence

ORD record
ord-e733ab621f884bedaf328ab2949c447c
Source dataset
uspto-grants-2002_11
Patent number
US06479531B1

Reaction notes

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