HCID 69686765, compound → HCID 54417419, compound

Participants

Reaction Steps

The product of step d (237 mg, 0.34 mmol) was dissolved in trifluoroacetic acid (2 ml) and the solution was stirred at room temperature for 1 h. The trifluroracetic acid was removed in vacuo. The residue was partitioned between DCM and saturated aqueous sodium hydrogen carbonate. The organic layer was dried (MgSO4) and the solvent was evaporated to afford the product as a white solid (190 mg, 94%). 1H NMR (300 MHz, CDCl3) 10.84 (1H, br s), 8.96 (1H, br s), 8.08 (1H, s), 7.75 (1H, d), 7.52 (1H, d), 7.47-7.27 (1OH, m), 6.86 (1H, s), 5.36 (2H, s), 2.65 (3H, s), 2.57 (2H, m), 1.95 (3H, br s), 1.65 (6H, m), 1.51 (6H, s), 1.37 (2H, m).

Provenance & Evidence