Benzyl Alcohol → HCID 57072059, compound

Participants

Reaction Steps

5-(2-Adamantan-1-yl-ethyl)-2-o-tolyl-imidazole-1,4-dicarboxylic acid 1-tert-butyl ester (Example 75, step c) was converted to the isocyanate and reacted with benzyl alcohol according to the procedure of Example 75, step d using benzyl alcohol in place of 3-amino-benzoic acid benzyl ester. The crude reaction mixture was purified by flash column chromatography (silica, hexane/ethyl acetate 3:2) to give the product. 1H NMR (300 MHz, CDCl3) 7.39-7.19 (9H, m), 6.10 (1H, br s), 5.20 (2H, s), 2.79 (2H, m), 2.18 (3H, s), 1.96 (3H, s), 1.68 (6H, m), 1.50 (6H, s), 1.31 (2H, m), 1.19 (9H, s).

Provenance & Evidence