3-amino-N-benzoyl-benzenesulfonamide → 5-(2-Adamantan-1-yl-ethyl)-2-o-tolyl-1H-imidazole-4-carboxylic Acid (3-benzoylsulfamoyl-phenyl)-amide

Participants

Reaction Steps

5-(2-Adamantan-1-yl-ethyl)-2-o-tolyl-1H-imidazole-4-carboxylic acid (Example 93) was reacted with 3-amino-N-benzoyl-benzenesulfonamide using essentially the same procedure as in Example 20, step d. The crude product was purified by flash column chromatography (silica, ethyl acetate/hexane 2:1) to afford the title compound. 1H NMR 300 MHz, d6-DMSO) 12.52 (1H, br s), 9.85 (1H, br s), 8.55 (1H, br s), 7.89 (3H, m), 7.62-7.29 (9H, m), 2.99 (2H, m), 2.54 (3H, s), 1.95 (3H, s), 1.66-1.40 (14H, m). Found: C, 67.51; H, 6.33; N, 8.63%; C36H38N4O4S.1.0 H2O requires: C, 67.48; H, 6.29; N, 8.74%.

Provenance & Evidence