Hydrochloric Acid → HCID 178424202, compound

Participants

Reaction Steps

To a solution of the product of step c (232 mg, 0.65 mmol) in ethanol (13 ml) was added 1M sodium hydroxide (1.3 ml, 1.3 mmol). The solution was refluxed for 2 h, diluted with water (10 ml), then acidified (pH=5, 0.01M HCl). The resulting precipitate was collected by filtration, washed with water and dried to give the title compound (271 mg, 86%). 1H NMR (300 MHz, d6-DMSO) 12.40 (1H, br s), 12.2 (1H, br s), 7.80-7.29 (8H, m), 6.98 (1H, br s), 3.23 (2H, m), 3.00 (2H, m), 2.44 (3H, s) 2.03 (9H, s), 1.65 (6H, s). The acid was converted to the N-methyl-D-glucamine salt and lyophilised from water/dioxan. Found: C, 58.98; H, 7.83; N, 7.40% C37H50N4O8.4H2O requires: C, 59.18 H, 7.79; N, 7.46%.

Provenance & Evidence