Phosphoric Acid → HCID 18405465, compound

Participants

Reaction Steps

A solution of the product from step b (540 mg, 1.37 mmol) in ethanol (48m1) and 2M sodium hydroxide (4.8 ml, 9.60 mmol) were refluxed for 16 h. The resulting hot suspension was acidified (pH=3, 1M H3PO4), the ethanol was evaporated, the residue was diluted with water and extracted with ethyl acetate. The organic layer was washed with water, dried (MgSO4), and the solvent was evaporated to afford the product as a white solid (460 mg, 92%). 1H NMR (300 MHz, CDCl3) 8.00 (1H, d), 7.33 (3H, m), 3.11 (2H, m), 2.70 (3H, s), 2.00 (3H, s), 1.77-1.49 (14H, m).

Provenance & Evidence