Benzoic acid, 3-amino-, methyl ester → HCID 69686376, compound

HRID 1018331Notes

Reaction equation

HRID 1018331 reaction equation
[C:1]12([CH2:11][CH2:12][C:13]3[N:14]=[C:15]([CH:21]4[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]4)[S:16][C:17]=3[C:18](O)=[O:19])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[CH3:27][O:28][C:29](=[O:37])[C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([NH2:36])[CH:31]=1>>[CH3:27][O:28][C:29](=[O:37])[C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([NH:36][C:18]([C:17]2[S:16][C:15]([CH:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[N:14][C:13]=2[CH2:12][CH2:11][C:1]23[CH2:2][CH:3]4[CH2:4][CH:5]([CH2:6][CH:7]([CH2:9]4)[CH2:8]2)[CH2:10]3)=[O:19])[CH:31]=1

Participants

3

Reactant 2

HCID 78274Benzoic acid, 3-amino-, methyl esterHCID 18405558HCID 18405558, compound

Product 1

HCID 69686376HCID 69686376, compoundYield 59%

Procedure

The product from step c was reacted with 3-amino-benzoic acid methyl ester using essentially the same method as in Example 52, step a. The product was obtained as a white solid in 59% yield. 1H NMR (300 MHz, CDCl3) 8.00 (2H, m), 7.82 (1H, d), 7.47 (2H, m), 3.93 (3H, s), 3.06 (3H, m), 2.18-1.27 (27H, m).

Workup

  1. customThe product was obtained as a white solid in 59% yield

Sources & evidence

ORD record
ord-cd70d55877d84527be035c5305959cd1
Source dataset
uspto-grants-2002_11
Patent number
US06479531B1

Reaction notes

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