反应详情

The title compound was synthesised following the procedure of Example 1, with the modification that 5-adamantan-1-yl-3-oxo-pentanoic acid ethyl ester was used instead of 4-adamantan-1-yl-3-oxo-butyric acid ethyl ester, and o-methyl-2-bromo-1-phenyl-ethanone was used instead of 2-bromo-1-phenyl-ethanone in step a, and 3-amino-benzoic acid benzyl ester replaced 5-amino-isophthalic acid dibenzyl ester in step d. 1H NMR (300 MHz, d6-DMSO) 13.0 (1H, br s), 11.22 (1H, s), 9.51 (1H, s), 8.32 (1H, s), 8.02 (1H, d), 7.60 (1H, d), 7.40 (2H, m), 7.25 (3H, m), 6.88 (1H, s), 2.95 (2H, m), 2.45 (3H, s), 1.94 (3H, s), 1.64 (6H, m), 1.53 (6H, s), 1.36 (2H, m). The acid was converted to the N-methyl-D-glucamine salt and lyophilised from water/dioxan. Found: C, 64.72; H, 7.77; N, 5.87%. C38H51N3O8.1.5 H2O requires: C, 64.72; H, 7.72, N, 5.96%.