反应详情

The title compound was prepared according to the procedure of Example 20, with the modification that o-tolualdehyde was used instead of 2-naphthaldehyde in step b, and 3-amino-benzoic acid benzyl ester replaced 5-amino-isophthalic acid dibenzyl ester in step d. 1H NMR (300 MHz, d6-DMSO) 13.00 (1H, br s), 12.52 (1H, br s), 9.78 (1H, s), 8.51 (1H, s), 7.93 (1H, m), 7.60 (2H, m), 7.41 (1H, t), 7.32 (3H, m), 2.93 (2H, d), 2.54 (3H, s), 2.00 (1H, m), 1.66-1.22 (12H, m). The acid was converted to the N-methyl-D-glucamine salt and lyophilised from water/dioxan. Found: C, 60.05; H, 7.70; N, 8.46%. C33H46N4O8.1.9 mols H2O requires: C, 60.03; H, 7.59; N, 8.49%.