HCID 11568581, compound → HCID 11548651, compound

Participants

Reaction Steps

The product of step d (0.76 g, 2.122 mmol) was reacted with 3-amino-benzoic acid benzyl ester (0.48 g, 2.12 mmol) according to the procedure of Example 20, step d. The crude material was purified by flash chromatography (silica, DCM/ethyl acetate 98:2, then 95:5) to afford colourless foam (786 mg, 65.5%). 1H NMR (300 MHz, CDCl3) 9.50 and 8.90 (1H, 2× br s), 8.15 (2H, m), 7.81 (1H, d), 7.40 (6H, m), 5.38 (2H, s), 4.98 (2H, br s), 2.71 (1H, m), 2.16 (3H, br s), 2.00 (2H, m), 1.85-1.24 (20H, m).

Provenance & Evidence