Methyl 5-amino-2-fluorobenzoate → HCID 18405481, compound

Participants

Reaction Steps

5-(2-Adamantan-1-yl-ethyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid (Example 252) was reacted with 5-amino-2-fluoro-benzoic acid methyl ester according to the procedure of Example 20, step d. The methyl ester was hydrolysed using the same procedure as in Example 36, step d to afford the title compound. 1H NMR (300 MHz, d6-DMSO) 10.79 (1H, br s), 8.32 (1H, dd), 7.97 (1H, m), 7.32 (1H, m), 2.91 (3H, m), 1.98-1.34 (27H, m). The acid was converted to the N-methyl-D-glucamine salt and lyophilised from water/dioxan. Found: C, 56.04; H, 8.48; N, 7.28%. C36H53FN4O8.4.5 mols H2O requires: C, 56.16; H, 8.12; N, 7.28%.

Provenance & Evidence