HCID 18405518, compound → HCID 18405559, compound

Participants

Reaction Steps

5-(2-Adamantan-1-yl-ethyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid (Example 252) was reacted with 2-(3-amino-phenyl)-2-methyl-propionic acid ethyl ester (prepared from 2-(4-chloro-phenyl)-2-methyl-propionic acid using Mutti's procedure (S. Mutti et al. Synth. Comm. 1997, 27, 425)) according to the procedure of Example 20, step d. The ethyl ester was hydrolysed using the same procedure as in Example 247, step b to afford the title compound. 1H NMR (300 MHz, d6-DMSO) 10.52 (1H, br s), 7.70 (2H, m), 7.32 (1H, m), 7.12 (1H, d), 2.93 (3H, m), 1.98-1.35 (33H, m). The acid was converted to the N-methyl-D-glucamine salt and lyophilised from water/dioxan. Found: C, 63.89; H, 8.61; N, 7.77%; C39H60N4O8.1.0 mol H2O requires: C, 64.09; H, 8.55; N, 7.67%.

Provenance & Evidence