HCID 18405518, compound → HCID 70120561, compound

Participants

Reaction Steps

5-(2-Adamantan-1-yl-ethyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid (Example 252) (690 mg, 1.94 mmol) was reacted with the product of step b (540 mg, 1.94 mmol) according to the procedure of Example 20, step d to afford colourless foam after purification by flash chromatography (silica, hexane/ethyl acetate 2:1) (287 mg, 24%). 1H NMR (300 MHz, CDCl3) 9.04 (1H, br s), 8.63 (1H, br s), 7.60 (2H, m), 7.25 (1H, m), 6.97 (1H, d), 5.11 (1H, m), 3.17-3.03 (4H, m), 2.80 (1H, m), 2.10-1.27 (399H, m).

Provenance & Evidence