Potassium Carbonate → HCID 69686403, compound

Participants

Reaction Steps

A solution of the product of step c (282 mg, 0.46 mmol) and potassium carbonate (96 mg, 0.70 mmol) in methanol (3 ml) and water (0.3 ml) was stirred at room temperature for 3 h. The reaction was quenched with 10% aqueous citric acid (1 ml), then diluted with ethyl acetate (20 ml). The organic phase was washed with water (20 ml), brine (20 ml), dried (MgSO4) and the solvent was evaporated. The residue was purified by flash chromatography (silica, hexane/ethyl acetate 2:1) to afford colourless foam (167 mg, 63%). 1H NMR (300 MHz, CDCl3) 9.05 (1H, br s), 8.62 (1H, br s), 7.60 (2H, m), 7.25 (1H, m), 6.98 (1H, d), 4.34 (1H, m), 3.13-3.02 (4H, m), 2.93 (1H, m), 2.85 (1H, d), 2.68 (1H, m), 2.05-1.35 (36H, m).

Provenance & Evidence