HCID 18405518, compound → HCID 57231403, compound

Participants

Reaction Steps

3-(5-Amino-2-chloro-phenyl)-acrylic acid methyl ester (prepared in two steps from 2-chloro-5-nitro-benzaldehyde) was reacted with 5-(2-adamantan-1-yl-ethyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid (Example 252) according to the procedure of Example 20, step d. The methyl ester was hydrolysed using the same procedure as in Example 36, step d to afford the title compound. 1H NMR (300 MHz, d6-DMSO) 10.80 (1H, br s), 8.25 (1H, d), 7.96 (1H, d), 7.87 (1H, d), 7.55 (1H, d), 6.44 (1H, d), 2.94 (3H, m), 1.98-1.33 (27H, m). The acid was converted to the N-methyl-D-glucamine salt and lyophilised from water/dioxan. Found: C, 55.45; H, 7.91; N, 6.97%. C38H55ClN4O8.5.0 mols H2O requires: C, 55.57; H, 7.98; N, 6.82%.

Provenance & Evidence