Water → HCID 69686851, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure given in Example 281, with the modification that 5-(2-adamantan-1-yl-ethyl)-2-cyclohexyl-1H-imidazole-4-carboxylic acid (Example 252) was used in step a instead of 5-(2-adamantan-1-yl-ethyl)-2-o-tolyl-1H-imidazole-4-carboxylic acid. 1H NMR (300 MHz, d4-MeOH) 7.94 (1H, dt), 7.84 (1H, t), 7.55 (1H, t), 7.46 (1H, ddd), 2.94 (2H, m), 2.77 (1H, m) 1.94 (7H, m), 1.70 (8H, m), 1.58 (7H, m), 1.42 (5H, m). The acid was converted to the N-methyl-D-glucamine salt and lyophilised from water/dioxan. Found: C, 61.32; H, 8.34; N, 5.87%. C36H53N3O9.1.9 mols H2O requires: C, 61.21; H, 8.11; N, 5.95%.

Provenance & Evidence