N-Methyl-D-glucamine → HCID 86758605, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure of Example 286, with the modification that (3-{[5-(adamantan-1-yloxymethyl)-2-cyclohexyl-1H-imidazole-4-carbonyl]-amino}-phenyl)-acetic acid (Example 219) was used in step a instead of 3-{[5-(adamantan-1-yloxymethyl)-2-cyclohexyl -1H-imidazole-4-carbonyl]-amino}-benzoic acid. 1H NMR (300 MHz, d6-DMSO) 12.15 (1H, s), 10.62 (1H, s), 9.37 (1H, s), 8.80 (1H, s), 7.68 (1H, s), 7.58 (1H, d), 7.21 (1H, t), 6.94 (1H, d), 4.79 (2H, s), 3.25 (2H, s), 2.69 (1H, m), 2.11 (3H, br s), 1.90 (2H, m), 1.75 (8H, m), 1.55 (8H, m), 1.30 (4H, m). The hydroxamic acid was converted to the N-methyl-D-glucamine salt and lyophilised from water/dioxan. Found: C, 59.81; H, 8.06; N, 9.68%; C36H55N5O9.1.1H2O requires: C, 59.87; H, 7.99; N, 9.70%.

Provenance & Evidence