Piperazine → HCID 23322302, compound

Participants

Reaction Conditions

Reaction Steps

68.8 g (1.0 mole) of limidazole and 260.6 g (3.0 mole) of piperazine were solved in 700.2 g of water and at a temperature of 50-60° C. 370 g (4.0 mole) of epichlorhydrin were added dropwise. After the addition was complete, the reaction mixture was stirred for additional 5 hours at 80° C. To 237 g of this product (equivalent to 1,022 mole of oxidizable nitrogen atoms) 80.7 g (1.12 mole) of a 47.2% solution of H202 in water were added over a period of 5 hours at 40° C. After that the mixture was heated to 50-60° C. until the theoretical amount of H202 had been consumed. Unreacted H202 was destroyed by using Pt/C and the solution then filtered.

Provenance & Evidence