Bromine → HCID 18401372, compound

HRID 1018419Notes

Reaction equation

HRID 1018419 reaction equation
[Br:1]Br.[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:14]=[C:13]([O:15][CH:16]([F:18])[F:17])[N:12]([CH3:19])[N:11]=2)=[CH:6][CH:5]=1>C(Cl)(Cl)(Cl)Cl>[Br:1][C:14]1[C:10]([C:7]2[CH:6]=[CH:5][C:4]([Cl:3])=[CH:9][CH:8]=2)=[N:11][N:12]([CH3:19])[C:13]=1[O:15][CH:16]([F:18])[F:17]

Participants

4

Reactant 2

HCID 24408BromineHCID 15220184HCID 15220184, compound

Product 1

HCID 18401372HCID 18401372, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

7.9 g (43 mmol) of bromine were added to a solution of 10.1 g (39 mmol) of 3-(4-chlorophenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole in 100 ml of carbon tetrachloride, and the mixture was then stirred for 16 h. The solution was then washed with sat. aqueous sodium bicarbonate solution, dried over magnesium sulfate and finally concentrated. Yield: 12.9 g. 1H-NMR (270 MHz, in CDCl3): δ[ppm]=3.84 (s, 3H), 6.69 (t, 1H), 7.40 (d, 2H), 7.81 (d, 2H).

Workup

  1. washThe solution was then washed with sat. aqueous sodium bicarbonate solution
  2. dry with materialdried over magnesium sulfate
  3. concentrationfinally concentrated

Sources & evidence

ORD record
ord-5d02123b22a143e3863af07c489e7422
Source dataset
uspto-grants-2002_11
Patent number
US06482774B1

Reaction notes

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