HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-Bromo-1-(4-nitrophenyl)-isochromane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Nitrobenzaldehyde | HCID 541 | — |
| Reactant | 2-(4-Bromophenyl)ethanol | HCID 72851 | — |
| Catalyst | Zincchloride | HCID 3007855 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 7-Bromo-1-(4-nitrophenyl)-isochromane | HCID 18401487 | — |
Reaction Steps
20.1 g (100 mM) of 2-(4-bromophenyl)-ethanol and 15.1 g (100 mM) of 4-nitrobenzaldehyde were dissolved in 300 ml of anhydrous benzene, then 13.6 g (100 mM) of anhydrous zinc chloride were added and dry hydrochloric acid gas was led into the stirred mixture for 4 hours. Then the process described under Examples 1-7, Step a) was applied. The crude product was recrystallized from ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06482819B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-8ac75809898240ffa4bcf3d7a00f6bbe |
| Source note | uspto-grants-2002_11 |