Selenium Dioxide → HCID 18401493, compound

Participants

Reaction Conditions

Reaction Steps

9.17 g (29.0 mM) of 8-chloro-4-methyl-1-(4-nitrophenyl)-5H-2,3-benzodiazepine (prepared according to the method described in Example 39) were dissolved in 120 ml of dioxane, then 2.27 g (20.5 mM) of selenium dioxide powder were added and the mixture was stirred on a 90° C. water bath for 40 minutes. Then the solution was treated with active carbon, filtered and poured into 1500 ml of water. The precipitated crystals were filtered and washed with water. The crude product was purified on a Kieselgel column using benzene as eluant.

Provenance & Evidence