HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(tert-butoxycarbonyl)-L-aspartic acid 1-benzyl ester 4-piperidinamide → N-(tert-butoxycarbonyl)-L-aspartic acid 4-piperidinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(tert-butoxycarbonyl)-L-aspartic acid 1-benzyl ester 4-piperidinamide | HCID 70086528 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(tert-butoxycarbonyl)-L-aspartic acid 4-piperidinamide | HCID 70086804 | — |
Reaction Steps
A solution of the compound from step A above (700 mg) in ethanol (30 mL) was exposed to a hydrogen atmosphere in the presence of 10% Pd-C (70 mg) for 4 hr at room temperature. After filtration (Celite filter aid) and rotoevaporation, N-(tert-butoxycarbonyl)-L-aspartic acid 4-piperidinamide (500 mg) was obtained as a yellowish foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06482827B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-5d71e31486be41f2a5bdc2ba1027a8f0 |
| Source note | uspto-grants-2002_11 |