1-Chloro-1-nitrosocyclohexane → 3,6-dihydro-3,5-dimethyl-6-(4-ethoxyphenyl)-2H-1,2-oxazine hydrochloride

Participants

Reaction Steps

To a solution of 1-chloro-1-nitrosocyclohexane (3.22 g, 21.86 mmol) in ethanol (2.31 ml) and diethyl ether (8 ml) cooled in an ice bath was added a solution of 1-(4-ethoxyphenyl)-2-methylpent-1E,3E-diene (4.0 g, 19.88 mmol) in diethyl ether (4 ml). The reaction vessel was sealed and kept in a fridge at 0° C. over a period of 4 weeks yielding three crops of 3,6-dihydro-3,5-dimethyl-6-(4-ethoxyphenyl)-2H-1,2-oxazine hydrochloride as white crystals.

Provenance & Evidence