Methanol → HCID 9863371, compound

Participants

Reaction Steps

A mixture of 0.75 ml of a 0.05M solution of 3,5-dimethyl-6-(4-methoxyphenyl)-3,6-dihydro-2H-1,2-oxazine in dichloromethane, 0.5 ml of a 0.05M solution of 4-methoxybenzoic acid in dimethylformamide, and 0.5 ml of a 0.075M solution of N-ethyl-N′-dimethylaminopropyl-carbodiimide hydrochloroide in acetonitrile was stirred at ambient temperature for 18 h. Methanol (1 ml) was added with stirring and the mixture applied to a methanol washed 500 mg Isolute SCX cartridge (Jones Chromatography). The absorbent was then washed with methanol (2.5 ml) and the combined run through and washing concentrated to dryness using a centrifugal evaporator. The residue was dissolved in ethyl acetate (0.5 ml) and applied to a 100 mg Isolute SI cartridge (Jones Chromatography). Elution with ethyl acetate (2 ml) followed by removal of the solvent by centrifugal evaporation gave 3,5-dimethyl-2-(4-methoxybenzoyl)-6-(4-methoxyphenyl)-3,6-dihydro-2H-1,2-oxazine.

Provenance & Evidence