Sodium Hydroxide → HCID 11759092, compound

Participants

Reaction Steps

A mixture of intermediate (9) (1.32 g) and phosphorous oxychloride (5 ml) was refluxed for 2 hours, cooled, poured onto ice and neutralized by 1N NaOH. The aqueous layer was extracted by ethyl acetate. The organic layer was washed with brine, dried, concentrated, yielding 2-methyl-4-chloro-8-(2′,4′-dichlorophenyl)quinoline (intermediate 1) (1.31 mg. 300 MHz 1H NMR (CDCl3): δ 2.58 (s, 3H), 7.34 (s, 2H), 7.39 (s,1H), 7.53 (s, 1H), 7.63-7.65 (m, 2H), 8.26 (dd,1H).

Provenance & Evidence