HCID 3290996, compound → HCID 22898679, compound

Participants

Reaction Steps

A mixture of 8 g (0.02 mol) de 4-(3-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl ester 5-(tetrahydrofuran-2-ylmethyl) ester, obtained according A), and 71 g (0.059 mol) of pyridinium chlorochromate absorbed on alumina, was suspended in 200 ml of CH2Cl2. Then, the whole mixture was maintained with stirring at room temperature, along 8 hours. The remaining solid was eliminated by filtration, and the liquid was washed with water (3×250 ml). dried over anh. Na2SO4, and concentrated at reduced pressure, to dryness. The product was obtained as an oil, which was purified by column chromatography (Silicagel, n-hexane:EtAcO, 8:2) with a yield of 70%.

Provenance & Evidence