HCID 69946311, compound → HCID 22898675, compound

HRID 1018510Notes

Reaction equation

HRID 1018510 reaction equation
[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][O:7][C:8]([C:10]1[CH:11]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[Br:28])[C:12]([C:18]([O:20][CH3:21])=[O:19])=[C:13]([CH3:17])[NH:14][C:15]=1[CH3:16])=[O:9].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][O:7][C:8]([C:10]1[C:11]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[Br:28])=[C:12]([C:18]([O:20][CH3:21])=[O:19])[C:13]([CH3:17])=[N:14][C:15]=1[CH3:16])=[O:9]

Participants

3

Reactant 2

HCID 69946311HCID 69946311, compoundHCID 178418287HCID 178418287, compound

Product 1

HCID 22898675HCID 22898675, compound

Procedure

A mixture of 10 g (0.022 mol) of 4-(2-bromophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl ester 5-(tetrahydrofuran-2-ylmethyl) ester, obtained according A), and 80 g (0.067 mol) of pyridinium chlorochromate absorbed on alumina, was suspended on 220 ml of CH2Cl2, and the mixture was stirred at room temperature for 6 hours.

Workup

  1. customobtained
  2. customabsorbed on alumina

Sources & evidence

ORD record
ord-8c655efd7e3a4d92a3d807714685a509
Source dataset
uspto-grants-2002_11
Patent number
US06482841B1

Reaction notes

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