HCID 69947162, compound → HCID 22898672, compound

Participants

Reaction Steps

A mixture of 12 g (0.027 mol) of 2,6-dimethyl-4-(3-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl ester 5-(tetrahydrofuran-2-ylmethyl) ester, obtained as described in A), and 98 g (0.082 mol) of pyridinium chlorochromate adsorbed on alumina, was suspended in 270 ml of CH2Cl2, and the suspension was maintained under stirring at room temperature for 6 hours. The remaining solid was eliminated by filtration, and the liquid was washed with water (3×300 ml), drive over anh. Na2SO4, and concentrated at reduced pressure, to dryness. The product was obtained as an oil, which was purified by column chromatography (Silicagel, n-hexane:EtAcO, 8:2) with a yield of 65%.

Provenance & Evidence