HCID 69944501, compound → HCID 22898680, compound

Participants

Reaction Steps

A mixture of 10 g (0.025 mol) of 4-(3-cyanophenyl)-2,6-dimethyl 1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl ester 5-(tetrahydrofuran-2-ylmethyl) ester, obtained as described in A), and 91 g (0.076 mol) of pyridinium chlorochromate adsorbed on alumina, was suspended on 250 ml of CH2Cl2, and the suspension was stirred at room temperature for 5 hours. The remaining solid was separated by filtration, and the organic solution was washed with water (3×150 ml), dried with anh. Na2SO4, and concentrated to dryness at reduced pressure. The product was obtained as an oil, which was purified by column chromatography (Silicagel, n-hexane:EtAcO, 8:2) with a yield of 78%.

Provenance & Evidence