HCID 5178648, compound → HCID 22898683, compound

Participants

Reaction Steps

A mixture of 9 g (0.020 mol) of 4-(4-chloro-3-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl ester 5-(tetrahydrofuran-2-ylmethyl) ester, obtained as described in A) in 72 g (0.060 mol) of pyridinium chlorochromate adsorbed on alumina, were suspended on 200 ml of CH2C12 then, the mixture was maintained with stirring at room temperature for 9 hours. The remaining solid was filtered, and the filtrate was washed with water (3×200 ml), dried with anh. Na2SO4, and the solvent evaporated under reduced pressure. The product was isolated as an oil, which was purified by column chromatography (Silicagel, n-hexane:EtAcO, 8:2) with a yield of 69%.

Provenance & Evidence