Garenoxacin mesylate hydrate → Garenoxacin mesylate

HRID 1018536Notes

Reaction equation

HRID 1018536 reaction equation
O.[CH3:2][S:3]([OH:6])(=[O:5])=[O:4].[CH:7]1([N:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([C:24]4[CH:25]=[C:26]5[C:30](=[CH:31][CH:32]=4)[C@@H:29]([CH3:33])[NH:28][CH2:27]5)[C:18]=3[O:20][CH:21]([F:23])[F:22])[C:13](=[O:34])[C:12]([C:35]([OH:37])=[O:36])=[CH:11]2)[CH2:9][CH2:8]1>C(O)C>[CH3:2][S:3]([OH:6])(=[O:5])=[O:4].[CH:7]1([N:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([C:24]4[CH:25]=[C:26]5[C:30](=[CH:31][CH:32]=4)[C@@H:29]([CH3:33])[NH:28][CH2:27]5)[C:18]=3[O:20][CH:21]([F:23])[F:22])[C:13](=[O:34])[C:12]([C:35]([OH:37])=[O:36])=[CH:11]2)[CH2:9][CH2:8]1

Participants

3

Reactant 1

HCID 157690Garenoxacin mesylate hydrate

Product 1

HCID 124094Garenoxacin mesylateYield 72.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 2 ml of ethanol is suspended 0.2 g of (R)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1H-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methanesulfonate monohydrate and the suspension is stirred at room temperature for 15 hours, and then subjected to collection by filtration to obtain 0.14 g of (R)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1H-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid methanesulfonate.

Workup

  1. filtrationsubjected to collection by filtration

Sources & evidence

ORD record
ord-49262806e869409a8b00751f3cfda2d1
Source dataset
uspto-grants-2002_11
Patent number
US06482835B2

Reaction notes

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