HRID1018551

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81668

1-(2-Chloroethyl)pyrrolidine hydrochloride

C6H13Cl2N

结构：O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)C(=O)NCN2c1ccccc1

HCID18401725

未命名化合物

PRODUCTS

生成物

结构：O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCC2(CC1)C(=O)N(CCN1CCCC1)CN2c1ccccc1

HCID18401659

未命名化合物

PROCEDURE

实验过程

The title compound, MS: m/e=569.2 (M+H+), was prepared in accordance with the general method of example 4 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one and 1-(2-chloroethyl)pyrrolidine hydrochloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4ca0462dcdeb4e24840cf66268a4c473
来源数据集: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06482829B2
来源说明: uspto-grants-2002_11

反应 SMILES

[F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1)[C:6]([N:8]1[CH2:24][CH2:23][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:14][NH:13][C:12]2=[O:22])[CH2:10][CH2:9]1)=[O:7].Cl.Cl[CH2:36][CH2:37][N:38]1[CH2:42][CH2:41][CH2:40][CH2:39]1>>[F:33][C:2]([F:1])([F:32])[C:3]1[CH:4]=[C:5]([CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1)[C:6]([N:8]1[CH2:9][CH2:10][C:11]2([N:15]([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:14][N:13]([CH2:36][CH2:37][N:38]3[CH2:42][CH2:41][CH2:40][CH2:39]3)[C:12]2=[O:22])[CH2:23][CH2:24]1)=[O:7]