Isopropylamine → 8-(3,5-Bis-trifluoromethyl-benzoyl)-3-(2-isopropylamino-ethyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one

HRID 1018566Notes

Reaction equation

HRID 1018566 reaction equation
[F:1][C:2]([F:37])([F:36])[C:3]1[CH:4]=[C:5]([CH:29]=[C:30]([C:32]([F:35])([F:34])[F:33])[CH:31]=1)[C:6]([N:8]1[CH2:28][CH2:27][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[CH2:14][N:13]([CH2:23][CH2:24]O)[C:12]2=[O:26])[CH2:10][CH2:9]1)=[O:7].[CH:38]([NH2:41])([CH3:40])[CH3:39]>>[F:1][C:2]([F:37])([F:36])[C:3]1[CH:4]=[C:5]([CH:29]=[C:30]([C:32]([F:34])([F:35])[F:33])[CH:31]=1)[C:6]([N:8]1[CH2:9][CH2:10][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[CH2:14][N:13]([CH2:23][CH2:24][NH:41][CH:38]([CH3:40])[CH3:39])[C:12]2=[O:26])[CH2:27][CH2:28]1)=[O:7]

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 184016568-(3,5-Bis-trifluoromethyl-benzoyl)-3-(2-hydroxy-ethyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one

Product 1

HCID 103034218-(3,5-Bis-trifluoromethyl-benzoyl)-3-(2-isopropylamino-ethyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one

Procedure

The title compound, MS: m/e=571.1 (M+H+), was prepared in accordance with the general method of example 48 from 8-(3,5-bis-trifluoromethyl-benzoyl)-3-(2-hydroxy-ethyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decan-4-one and isopropylamine.

Sources & evidence

ORD record
ord-67074994387a4adba2bc022dc8cfb040
Source dataset
uspto-grants-2002_11
Patent number
US06482829B2

Reaction notes

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