N,N-Dimethylaminoethyl chloride hydrochloride → HCID 18401610, compound

HRID 1018574Notes

Reaction equation

HRID 1018574 reaction equation
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:4]=[C:5]([CH:26]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:28]=1)[C:6]([N:8]1[CH2:25][CH2:24][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[Cl:22])[CH2:14][NH:13][C:12]2=[O:23])[CH2:10][CH2:9]1)=[O:7].Cl.Cl[CH2:37][CH2:38][N:39]([CH3:41])[CH3:40]>>[F:32][C:29]([F:31])([F:30])[C:27]1[CH:26]=[C:5]([CH:4]=[C:3]([C:2]([F:1])([F:33])[F:34])[CH:28]=1)[C:6]([N:8]1[CH2:9][CH2:10][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[Cl:22])[CH2:14][N:13]([CH2:37][CH2:38][N:39]([CH3:41])[CH3:40])[C:12]2=[O:23])[CH2:24][CH2:25]1)=[O:7]

Participants

3

Reactant 2

HCID 11636816N,N-Dimethylaminoethyl chloride hydrochlorideHCID 18401647HCID 18401647, compound

Product 1

HCID 18401610HCID 18401610, compound

Procedure

The title compound, MS: m/e=577.0 (M+H+), was prepared in accordance with the general method of example 71 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-(2-chloro-phenyl)-1,3,8-triaza-spiro[4.5]decan-4-one and 1-chloro-2-dimethylaminoethane hydrochloride.

Sources & evidence

ORD record
ord-bd2bfefdc7504ae1a2762799b6ece17d
Source dataset
uspto-grants-2002_11
Patent number
US06482829B2

Reaction notes

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