1-(2-Chloroethyl)pyrrolidine → HCID 18401687, compound

HRID 1018586Notes

Reaction equation

HRID 1018586 reaction equation
[CH2:1]([N:8]1[C:12]2([CH2:17][CH2:16][N:15]([C:18](=[O:33])[C:19]3[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:20]=3)[CH2:14][CH2:13]2)[C:11](=[O:34])[NH:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:35][CH2:36][CH2:37][N:38]1[CH2:42][CH2:41][CH2:40][CH2:39]1>>[ClH:35].[CH2:1]([N:8]1[C:12]2([CH2:17][CH2:16][N:15]([C:18](=[O:33])[C:19]3[CH:20]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:22]=[C:23]([C:25]([F:26])([F:27])[F:28])[CH:24]=3)[CH2:14][CH2:13]2)[C:11](=[O:34])[N:10]([CH2:36][CH2:37][N:38]2[CH2:42][CH2:41][CH2:40][CH2:39]2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 816691-(2-Chloroethyl)pyrrolidineHCID 18401636HCID 18401636, compound

Product 1

HCID 18401687HCID 18401687, compound

Procedure

The title compound, MS: m/e=583.2 (M+H+), was prepared in accordance with the general method of example 71 from 1-benzyl-8-(3,5-bis-trifluoromethyl-benzoyl)-1,3,8-triaza-spiro[4.5]decan-4-one and 1-(2-chloroethyl)-pyrrolidine.

Sources & evidence

ORD record
ord-a3781664f7d5425fa82de26762bf6782
Source dataset
uspto-grants-2002_11
Patent number
US06482829B2

Reaction notes

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