3-Chlorobenzaldehyde → HCID 18401661, compound

HRID 1018587Notes

Reaction equation

[CH2:1]([N:8]1[C:12]2([CH2:17][CH2:16][N:15]([C:18](=[O:33])[C:19]3[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:20]=3)[CH2:14][CH2:13]2)[C:11](=[O:34])[N:10]([CH3:35])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:36]C1C=C(C=CC=1)C=O>>[F:28][C:25]([F:26])([F:27])[C:23]1[CH:24]=[C:19]([CH:20]=[C:21]([C:29]([F:32])([F:31])[F:30])[CH:22]=1)[C:18]([N:15]1[CH2:16][CH2:17][C:12]2([N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[C:6]([Cl:36])[CH:7]=3)[CH2:9][N:10]([CH3:35])[C:11]2=[O:34])[CH2:13][CH2:14]1)=[O:33]

Participants

Reactant 2

HCID 114773-Chlorobenzaldehyde

HCID 18401641HCID 18401641, compound

Product 1

HCID 18401661HCID 18401661, compound

Procedure

The title compound, MS: m/e=534.2 (M+H+), was prepared in accordance with the general method of example 88 from 1-benzyl-8-(3,5-bis-trifluoromethyl-benzoyl)-3-methyl-1,3,8-triaza-spiro[4.5]decan-4-one and 3-chlorobenzaldehyde.

Sources & evidence

ORD record: ord-480f321fbb7344bc954ac9a8f41bb3be
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06482829B2

Reaction notes

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