1-(2-Chloroethyl)pyrrolidine → HCID 10188510, compound

HRID 1018590Notes

Reaction equation

HRID 1018590 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)C1C=CC=CC=1.[F:15][C:16]([F:48])([F:47])[C:17]1[CH:18]=[C:19]([CH:40]=[C:41]([C:43]([F:46])([F:45])[F:44])[CH:42]=1)[C:20]([N:22]1[CH2:39][CH2:38][C:25]2([N:29]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:28]([CH3:36])[NH:27][C:26]2=[O:37])[CH2:24][CH2:23]1)=[O:21].ClCCN1CCCC1>>[F:48][C:16]([F:15])([F:47])[C:17]1[CH:18]=[C:19]([CH:40]=[C:41]([C:43]([F:46])([F:45])[F:44])[CH:42]=1)[C:20]([N:22]1[CH2:23][CH2:24][C:25]2([N:29]([C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH:28]([CH3:36])[N:27]([CH2:12][CH2:13][N:8]3[CH2:1][CH2:11][CH2:10][CH2:9]3)[C:26]2=[O:37])[CH2:38][CH2:39]1)=[O:21]

Participants

3

Reactant 2

HCID 816691-(2-Chloroethyl)pyrrolidineHCID 131723644HCID 131723644, compound

Product 1

HCID 10188510HCID 10188510, compound

Procedure

The title compound, MS: m/e=583.2 (M+H+), was prepared in accordance with the general method of example 99 from (rac)-8-(3,5-bis-trifluoromethyl-benzoyl)-2-methyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 1-benzyl-piperidin-4-one and 1-(2-chloroethyl)pyrrolidine.

Sources & evidence

ORD record
ord-6e5bba430e594dcba68c7b1e5abcff2d
Source dataset
uspto-grants-2002_11
Patent number
US06482829B2

Reaction notes

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