4-(Chloromethyl)-2-methyl-1,3-thiazole → HCID 87854808, compound

HRID 1018591Notes

Reaction equation

HRID 1018591 reaction equation
C(N1CCC(=O)CC1)C1C=CC=CC=1.[F:15][C:16]([F:48])([F:47])[C:17]1[CH:18]=[C:19]([CH:40]=[C:41]([C:43]([F:46])([F:45])[F:44])[CH:42]=1)[C:20]([N:22]1[CH2:39][CH2:38][C:25]2([N:29]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH:28]([CH3:36])[NH:27][C:26]2=[O:37])[CH2:24][CH2:23]1)=[O:21].Cl[CH2:50][C:51]1[N:52]=[C:53]([CH3:56])[S:54][CH:55]=1>>[F:48][C:16]([F:15])([F:47])[C:17]1[CH:18]=[C:19]([CH:40]=[C:41]([C:43]([F:46])([F:45])[F:44])[CH:42]=1)[C:20]([N:22]1[CH2:23][CH2:24][C:25]2([N:29]([C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)[CH:28]([CH3:36])[N:27]([CH2:50][C:51]3[N:52]=[C:53]([CH3:56])[S:54][CH:55]=3)[C:26]2=[O:37])[CH2:38][CH2:39]1)=[O:21]

Participants

3

Reactant 2

HCID 7363414-(Chloromethyl)-2-methyl-1,3-thiazoleHCID 131723644HCID 131723644, compound

Product 1

HCID 87854808HCID 87854808, compound

Procedure

The title compound, MS: m/e=597.0 (M+H+), was prepared in accordance with the general method of example 99 from (rac)-8-(3,5-bis-trifluoromethyl-benzoyl)-2-methyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 1-benzyl-piperidin-4-one and 4-chloromethyl-2-methylthiazole.

Sources & evidence

ORD record
ord-a757bfd2c2594eb8a2af01bd7a0b1839
Source dataset
uspto-grants-2002_11
Patent number
US06482829B2

Reaction notes

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