Isoxazole, 4-(chloromethyl)-3,5-dimethyl- → 8-(3,5-Bis-trifluoromethyl-benzoyl)-3-(3,5-dimethyl-isoxazol-4-yl-methyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione

HRID 1018600Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1018600
[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[C:6]([N:8]1[CH2:26][CH2:25][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[C:14](=[O:23])[NH:13][C:12]2=[O:24])[CH2:10][CH2:9]1)=[O:7].Cl[CH2:37][C:38]1[C:39]([CH3:44])=[N:40][O:41][C:42]=1[CH3:43]>>[F:35][C:2]([F:1])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[C:6]([N:8]1[CH2:26][CH2:25][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[C:14](=[O:23])[N:13]([CH2:37][C:38]3[C:39]([CH3:44])=[N:40][O:41][C:42]=3[CH3:43])[C:12]2=[O:24])[CH2:10][CH2:9]1)=[O:7]

Komponenten

3

Edukt 2

HCID 88246Isoxazole, 4-(chloromethyl)-3,5-dimethyl-HCID 101177418-(3,5-Bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione

Produkt 1

HCID 184016358-(3,5-Bis-trifluoromethyl-benzoyl)-3-(3,5-dimethyl-isoxazol-4-yl-methyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione

Versuchsvorschrift

The title compound, MS: m/e=609.0 (M+H+), was prepared in accordance with the general method of example 99 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione and 4-(chloromethyl)-3,5-dimethylisoxazole.

Quellen und Nachweise

ORD-Eintrag
ord-84a77c6bb3f04b489c5cea630bea01a7
Quelldatensatz
uspto-grants-2002_11
Patentnummer
US06482829B2

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