HRID1018601

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID78571

2-(Chloromethyl)-1H-benzimidazole

C8H7ClN2

结构：Cc1ccccc1N1C(=O)NC(=O)C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2

HCID10117741

未命名化合物

PRODUCTS

生成物

结构：Cc1ccccc1N1C(=O)N(Cc2nc3ccccc3[nH]2)C(=O)C12CCN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)CC2

HCID10168161

未命名化合物

PROCEDURE

实验过程

The title compound, MS: m/e=630.0 (M+H+), was prepared in accordance with the general method of example 99 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione and 2-(chloromethyl)-benzimidazole.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-13893b9a6de449b3af20e140bfe790c5
来源数据集: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06482829B2
来源说明: uspto-grants-2002_11

反应 SMILES

[F:1][C:2]([F:35])([F:34])[C:3]1[CH:4]=[C:5]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[C:6]([N:8]1[CH2:26][CH2:25][C:11]2([N:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH3:22])[C:14](=[O:23])[NH:13][C:12]2=[O:24])[CH2:10][CH2:9]1)=[O:7].Cl[CH2:37][C:38]1[NH:39][C:40]2[CH:46]=[CH:45][CH:44]=[CH:43][C:41]=2[N:42]=1>>[NH:39]1[C:40]2[CH:46]=[CH:45][CH:44]=[CH:43][C:41]=2[N:42]=[C:38]1[CH2:37][N:13]1[C:12](=[O:24])[C:11]2([CH2:25][CH2:26][N:8]([C:6](=[O:7])[C:5]3[CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=[C:3]([C:2]([F:1])([F:34])[F:35])[CH:4]=3)[CH2:9][CH2:10]2)[N:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[CH3:22])[C:14]1=[O:23]