HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-2-methyl-1,3-thiazole → 8-(3,5-Bis-trifluoromethyl-benzoyl)-3-(2-methyl-thiazol-4-yl-methyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-2-methyl-1,3-thiazole | HCID 736341 | — |
| Reactant | 8-(3,5-Bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione | HCID 10117741 | — |
| Product | 8-(3,5-Bis-trifluoromethyl-benzoyl)-3-(2-methyl-thiazol-4-yl-methyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione | HCID 10167811 | — |
Reaction Steps
The title compound, MS: m/e=611.0 (M+H+), was prepared in accordance with the general method of example 99 from 8-(3,5-bis-trifluoromethyl-benzoyl)-1-o-tolyl-1,3,8-triaza-spiro[4.5]decane-2,4-dione and 4-chloromethyl-2-methylthiazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06482829B2 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-17be6297ca85424bac21262e1031c9c4 |
| Source note | uspto-grants-2002_11 |